1EX8

CRYSTAL STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH HP4A, THE TWO-SUBSTRATE-MIMICKING INHIBITOR

Summary for 1EX8

Entry DOI	10.2210/pdb1ex8/pdb
Related	1CBK 1DY3 1EQ0 1EQM 1EQO 1HKA
Descriptor	6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	pyrophosphokinase, pyrophosphoryl transfer, folate, hppk, pterin, atp, bisubstrate-mimicking inhibitor, antimicrobial agent, drug design, substrate specificity, active-site architecture, transferase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	18790.62
Authors	Blaszczyk, J.,Ji, X. (deposition date: 2000-05-01, release date: 2001-05-01, Last modification date: 2023-08-30)
Primary citation	Shi, G.,Blaszczyk, J.,Ji, X.,Yan, H. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J.Med.Chem., 44:1364-1371, 2001 Cited by PubMed: 11311059 DOI: 10.1021/jm0004493 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation