1Q0N

CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE FROM E. COLI WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 1.25 ANGSTROM RESOLUTION

Replaces:  1EQO

Summary for 1Q0N

• Entry DOI: 10.2210/pdb1q0n/pdb
• Related: 1CBK 1DY3 1EQ0 1EQM 1EQO 1EX8 1F9H 1F9Y 1G4C 1HKA 1HQ2 1IM6 1KBR
• Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: pyrophosphokinase, pyrophosphoryl transfer, folate, hppk, pterin, 6-hydroxymethyl-7, 8-dihydropterin, ternary complex, substrate specificity, antimicrobial agent, drug design, transferase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 18987.16

Authors

Blaszczyk, J.,Ji, X. (deposition date: 2003-07-16, release date: 2003-08-26, Last modification date: 2023-08-30)

• Primary citation: Blaszczyk, J.,Shi, G.,Yan, H.,Ji, X.; Catalytic Center Assembly of Hppk as Revealed by the Crystal Structure of a Ternary Complex at 1.25 A Resolution; Structure, 8:1049-1058, 2000; PubMed: 11080626; DOI: 10.1016/S0969-2126(00)00502-5

Experimental method

X-RAY DIFFRACTION (1.25 Å)