1EV2

CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)

1EV2 の概要

• エントリーDOI: 10.2210/pdb1ev2/pdb
• 関連するPDBエントリー: 1CVS 1EVT
• 分子名称: PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION, ... (4 entities in total)
• 機能のキーワード: immunoglobulin (ig)like domains belonging to the i-set subgroup within ig-like domains, b-trefoil fold, growth factor-growth factor receptor complex, growth factor/growth factor receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 159389.34

構造登録者

Plotnikov, A.N.,Hubbard, S.R.,Schlessinger, J.,Mohammadi, M. (登録日: 2000-04-19, 公開日: 2000-05-31, 最終更新日: 2021-11-03)

• 主引用文献: Plotnikov, A.N.,Hubbard, S.R.,Schlessinger, J.,Mohammadi, M.; Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.; Cell(Cambridge,Mass.), 101:413-424, 2000; PubMed: 10830168; DOI: 10.1016/S0092-8674(00)80851-X

実験手法

X-RAY DIFFRACTION (2.2 Å)