1EER

CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS

1EER の概要

• エントリーDOI: 10.2210/pdb1eer/pdb
• 分子名称: ERYTHROPOIETIN, ERYTHROPOIETIN RECEPTOR (3 entities in total)
• 機能のキーワード: erythropoietin, erythropoietin receptor, signal transduction, hematopoietic cytokine, cytokine receptor class 1, complex (cytokine-receptor), complex (cytokine-receptor) complex, complex (cytokine/receptor)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01588; Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted: P19235
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 68844.19

構造登録者

Syed, R.S.,Li, C. (登録日: 1998-07-24, 公開日: 1999-10-01, 最終更新日: 2021-11-03)

• 主引用文献: Syed, R.S.,Reid, S.W.,Li, C.,Cheetham, J.C.,Aoki, K.H.,Liu, B.,Zhan, H.,Osslund, T.D.,Chirino, A.J.,Zhang, J.,Finer-Moore, J.,Elliott, S.,Sitney, K.,Katz, B.A.,Matthews, D.J.,Wendoloski, J.J.,Egrie, J.,Stroud, R.M.; Efficiency of signalling through cytokine receptors depends critically on receptor orientation.; Nature, 395:511-516, 1998; PubMed: 9774108; DOI: 10.1038/26773

実験手法

X-RAY DIFFRACTION (1.9 Å)