1EC3

HIV-1 protease in complex with the inhibitor MSA367

Summary for 1EC3

• Entry DOI: 10.2210/pdb1ec3/pdb
• Related: 1AJV 1AJX 1D4H 1D4I 1D4J 1EBW 1EBY 1EBZ 1EC0 1EC1 1EC2
• Descriptor: HIV-1 PROTEASE, N,N-[2,5-O-DIBENZYL-GLUCARYL]-DI-[VALINYL-AMINOMETHANYL-PYRIDINE] (3 entities in total)
• Functional Keywords: dimer, protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
• Total number of polymer chains: 2
• Total formula weight: 22376.41

Authors

Unge, T. (deposition date: 2000-01-25, release date: 2002-06-26, Last modification date: 2024-02-07)

• Primary citation: Andersson, H.O.,Fridborg, K.,Lowgren, S.,Alterman, M.,Muhlman, A.,Bjorsne, M.,Garg, N.,Kvarnstrom, I.,Schaal, W.,Classon, B.,Karlen, A.,Danielsson, U.H.,Ahlsen, G.,Nillroth, U.,Vrang, L.,Oberg, B.,Samuelsson, B.,Hallberg, A.,Unge, T.; Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors; Eur.J.Biochem., 270:1746-1758, 2003; PubMed: 12694187; DOI: 10.1046/j.1432-1033.2003.03533.x

Experimental method

X-RAY DIFFRACTION (1.8 Å)