1EC2
HIV-1 protease in complex with the inhibitor BEA428
Summary for 1EC2
Entry DOI | 10.2210/pdb1ec2/pdb |
Related | 1AJV 1AJX 1D4H 1D4I 1D4J 1EBW 1EBY 1EBZ 1EC0 1EC1 1EC3 |
Descriptor | HIV-1 PROTEASE, N,N-[2,5-O-[DI-4-PYRIDIN-3-YL-BENZYL]-GLUCARYL]-DI-[VALYL-AMIDO-METHANE] (3 entities in total) |
Functional Keywords | dimer, protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
Total number of polymer chains | 2 |
Total formula weight | 22376.41 |
Authors | Unge, T. (deposition date: 2000-01-25, release date: 2002-06-26, Last modification date: 2024-02-07) |
Primary citation | Andersson, H.O.,Fridborg, K.,Lowgren, S.,Alterman, M.,Muhlman, A.,Bjorsne, M.,Garg, N.,Kvarnstrom, I.,Schaal, W.,Classon, B.,Karlen, A.,Danielsson, U.H.,Ahlsen, G.,Nillroth, U.,Vrang, L.,Oberg, B.,Samuelsson, B.,Hallberg, A.,Unge, T. Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors Eur.J.Biochem., 270:1746-1758, 2003 Cited by PubMed: 12694187DOI: 10.1046/j.1432-1033.2003.03533.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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