1E7W

One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes

Summary for 1E7W

Entry DOI	10.2210/pdb1e7w/pdb
Descriptor	PTERIDINE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (5 entities in total)
Functional Keywords	dihydrofolate reductase, pteridine reductase, shortchain dehydrogenase, methotrexate resistance, oxidoreductase
Biological source	LEISHMANIA MAJOR
Total number of polymer chains	2
Total formula weight	64031.62
Authors	Gourley, D.G.,Hunter, W.N. (deposition date: 2000-09-11, release date: 2001-09-06, Last modification date: 2024-05-08)
Primary citation	Gourley, D.G.,Schuttelkopf, A.,Leonard, G.,Luba, J.,Hardy, L.,Beverley, S.,Hunter, W.N. Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites. Nat.Struct.Biol., 8:521-, 2001 Cited by PubMed: 11373620 DOI: 10.1038/88584 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation