1E7U

Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine

1E7U の概要

• エントリーDOI: 10.2210/pdb1e7u/pdb
• 分子名称: PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE (3 entities in total)
• 機能のキーワード: phosphoinositide 3-kinase gamma, secondary messenger generation, pi3k, pi 3k, wortmannin
• 由来する生物種: SUS SCROFA (WILD BOAR)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 110380.99

構造登録者

Walker, E.H.,Perisic, O.,Ried, C.,Stephens, L.,Williams, R.L. (登録日: 2000-09-08, 公開日: 2000-11-17, 最終更新日: 2023-12-13)

• 主引用文献: Walker, E.H.,Pacold, M.E.,Perisic, O.,Stephens, L.,Hawkins, P.T.,Whymann, M.P.,Williams, R.L.; Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine; Mol.Cell, 6:909-, 2000; PubMed: 11090628; DOI: 10.1016/S1097-2765(05)00089-4

実験手法

X-RAY DIFFRACTION (2 Å)