1DRB

CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING

Summary for 1DRB

DescriptorDIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ... (6 entities in total)
Functional Keywordsoxidoreductase
Biological sourceEscherichia coli
Total number of polymer chains2
Total molecular weight37128.76
Authors
David, C.,Kraut, J. (deposition date: 1991-11-06, release date: 1994-01-31, Last modification date: 2017-11-29)
Primary citation
Bystroff, C.,Kraut, J.
Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
Biochemistry, 30:2227-2239, 1991
PubMed: 1998681 (PDB entries with the same primary citation)
DOI: 10.1021/bi00222a028
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.96 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers170.3%4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report