1DJP

CRYSTAL STRUCTURE OF PSEUDOMONAS 7A GLUTAMINASE-ASPARAGINASE WITH THE INHIBITOR DON COVALENTLY BOUND IN THE ACTIVE SITE

Summary for 1DJP

• Entry DOI: 10.2210/pdb1djp/pdb
• Related: 1DJO 4PGA
• Descriptor: GLUTAMINASE-ASPARAGINASE, 5,5-dihydroxy-6-oxo-L-norleucine (3 entities in total)
• Functional Keywords: pga, glutaminase, asparaginase, don, 6-diazo-5-oxo-l-norvaline, glutaminase-asparaginase, suicide inhibitor, covalently bound inhibitor, hydrolase
• Biological source: Pseudomonas sp.
• Cellular location: Periplasm: P10182
• Total number of polymer chains: 2
• Total formula weight: 71146.36

Authors

Ortlund, E.,Lacount, M.W.,Lewinski, K.,Lebioda, L. (deposition date: 1999-12-03, release date: 2000-01-24, Last modification date: 2017-10-04)

• Primary citation: Ortlund, E.,Lacount, M.W.,Lewinski, K.,Lebioda, L.; Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu.; Biochemistry, 39:1199-1204, 2000; PubMed: 10684596; DOI: 10.1021/bi991797d

Experimental method

X-RAY DIFFRACTION (1.9 Å)