1DIG
HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY374571
1DIG の概要
エントリーDOI | 10.2210/pdb1dig/pdb |
関連するPDBエントリー | 1A4I 1DIA 1DIB |
分子名称 | METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [[N'-(2,5-DIAMINO-6-HYDROXY-PYRIMIDIN-4-YL)-UREAYL]-PHEN-4-YL]-CARBONYL-GLUTAMIC ACID, ... (5 entities in total) |
機能のキーワード | tetrahydrofolate, dehydrogenase, cyclohydrolase, nadp, inhibitor, rossmann fold, oxidoreductase, hydrolase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: P11586 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 68656.06 |
構造登録者 | Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M. (登録日: 1999-11-29, 公開日: 2000-07-05, 最終更新日: 2024-02-07) |
主引用文献 | Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry, 39:6325-6335, 2000 Cited by PubMed: 10828945DOI: 10.1021/bi992734y 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
構造検証レポート
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