1DIB

HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY345899

1DIB の概要

• エントリーDOI: 10.2210/pdb1dib/pdb
• 関連するPDBエントリー: 1A4I 1DIA 1DIG
• 分子名称: METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMI C ACID, ... (4 entities in total)
• 機能のキーワード: dehydrogenase, cyclohydrolase, nadp, inhibitor, rossmann fold, oxidoreductase, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P11586
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68635.07

構造登録者

Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M. (登録日: 1999-11-29, 公開日: 2000-07-05, 最終更新日: 2024-02-07)

• 主引用文献: Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M.; Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.; Biochemistry, 39:6325-6335, 2000; PubMed: 10828945; DOI: 10.1021/bi992734y

実験手法

X-RAY DIFFRACTION (2.7 Å)