1DHK
STRUCTURE OF PORCINE PANCREATIC ALPHA-AMYLASE
Summary for 1DHK
| Entry DOI | 10.2210/pdb1dhk/pdb |
| Descriptor | PORCINE PANCREATIC ALPHA-AMYLASE, BEAN LECTIN-LIKE INHIBITOR, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
| Functional Keywords | pancreatic alpha-amylase, porcine, lectin-like inhibitor, complex (hydrolase-inhibitor), complex (hydrolase-inhibitor) complex, complex (hydrolase/inhibitor) |
| Biological source | Sus scrofa (pig) More |
| Total number of polymer chains | 2 |
| Total formula weight | 81439.54 |
| Authors | Bompard-Gilles, C.,Payan, F. (deposition date: 1996-10-14, release date: 1997-12-24, Last modification date: 2024-10-23) |
| Primary citation | Bompard-Gilles, C.,Rousseau, P.,Rouge, P.,Payan, F. Substrate mimicry in the active center of a mammalian alpha-amylase: structural analysis of an enzyme-inhibitor complex. Structure, 4:1441-1452, 1996 Cited by PubMed Abstract: alpha-Amylases catalyze the hydrolysis of glycosidic linkages in starch and other related polysaccharides. The alpha-amylase inhibitor (alpha-Al) from the bean Phaseolus vulgaris belongs to a family of plant defence proteins and is a potent inhibitor of mammalian alpha-amylases. The structure of pig pancreatic alpha-amylase (PPA) in complex with both a carbohydrate inhibitor (acarbose) and a proteinaceous inhibitor (Tendamistat) is known, but the catalytic mechanism is poorly understood. PubMed: 8994970DOI: 10.1016/S0969-2126(96)00151-7 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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