1D8F
CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A PIPERAZINE BASED INHIBITOR.
Summary for 1D8F
Entry DOI | 10.2210/pdb1d8f/pdb |
Related | 1CQR 1D5J 1D7X |
Descriptor | STROMELYSIN-1 PRECURSOR, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | mixed alpha beta structure, zinc protease, inhibited, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (Probable): P08254 |
Total number of polymer chains | 2 |
Total formula weight | 39784.64 |
Authors | Cheng, M.Y.,De, B.,Pikul, S.,Almstead, N.G.,Natchus, M.G.,Anastasio, M.V.,McPhail, S.J.,Snider, C.E.,Taiwo, Y.O.,Chen, L.Y. (deposition date: 1999-10-22, release date: 2000-10-23, Last modification date: 2024-02-07) |
Primary citation | Cheng, M.,De, B.,Pikul, S.,Almstead, N.G.,Natchus, M.G.,Anastasio, M.V.,McPhail, S.J.,Snider, C.E.,Taiwo, Y.O.,Chen, L.,Dunaway, C.M.,Gu, F.,Dowty, M.E.,Mieling, G.E.,Janusz, M.J.,Wang-Weigand, S. Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. J.Med.Chem., 43:369-380, 2000 Cited by PubMed: 10669564DOI: 10.1021/jm990366q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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