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1D4K

HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR

Summary for 1D4K
Entry DOI10.2210/pdb1d4k/pdb
Related1b6k 1b6m
DescriptorHIV-1 PROTEASE, SULFATE ION, N-13-[(10S,13S)-9,12-DIOXO-10-(2-BUTYL)-2-OXA-8,11-DIAZABICYCLO [13.2.2] NONADECA-15,17,18-TRIENE] (2R)-BENZYL-(4S)-HYDROXY-5-AMINOPENTANOIC (1R)-HYDROXY-(2S)-INDANEAMIDE, ... (4 entities in total)
Functional Keywordshiv, protease, inhibitor, antiviral, hydrolase
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
Total number of polymer chains2
Total formula weight22422.39
Authors
Primary citationTyndall, J.D.,Reid, R.C.,Tyssen, D.P.,Jardine, D.K.,Todd, B.,Passmore, M.,March, D.R.,Pattenden, L.K.,Bergman, D.A.,Alewood, D.,Hu, S.H.,Alewood, P.F.,Birch, C.J.,Martin, J.L.,Fairlie, D.P.
Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.
J.Med.Chem., 43:3495-3504, 2000
Cited by
PubMed: 11000004
DOI: 10.1021/jm000013n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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