1D4K
HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 PROTEASE | polymer | 99 | 10765.7 | 2 | UniProt (P03369) Pfam (PF00077) | ||
| 2 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | E (A) | N-13-[(10S,13S)-9,12-DIOXO-10-(2-BUTYL)-2-OXA-8,11-DIAZABICYCLO [13.2.2] NONADECA-15,17,18-TRIENE] (2R)-BENZYL-(4S)-HYDROXY-5-AMINOPENTANOIC (1R)-HYDROXY-(2S)-INDANEAMIDE | non-polymer | 698.9 | 1 | Chemie (PI8) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 63 | engineered mutation |
| Ile 33 | Leu 89 | engineered mutation |
| Aba 67 | Cys 123 | engineered mutation |
| Aba 95 | Cys 151 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21531.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 891.0 | |
| All* | Total formula weight | 22422.4 |
