1CVU
CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
Summary for 1CVU
Entry DOI | 10.2210/pdb1cvu/pdb |
Related | 1CQE 1LOX 5COX 6COX |
Descriptor | PROSTAGLANDIN H2 SYNTHASE-2, PROTEIN (9-MER), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | cox-2, cyclooxygenase, prostaglandin, arachidonate, endoperoxide, oxidoreductase-peptide complex, oxidoreductase/peptide |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 3 |
Total formula weight | 132599.08 |
Authors | Kiefer, J.R.,Pawlitz, J.L.,Moreland, K.T.,Stegeman, R.A.,Gierse, J.K.,Stevens, A.M.,Goodwin, D.C.,Rowlinson, S.W.,Marnett, L.J.,Stallings, W.C.,Kurumbail, R.G. (deposition date: 1999-08-24, release date: 2000-05-16, Last modification date: 2021-11-03) |
Primary citation | Kiefer, J.R.,Pawlitz, J.L.,Moreland, K.T.,Stegeman, R.A.,Hood, W.F.,Gierse, J.K.,Stevens, A.M.,Goodwin, D.C.,Rowlinson, S.W.,Marnett, L.J.,Stallings, W.C.,Kurumbail, R.G. Structural insights into the stereochemistry of the cyclooxygenase reaction. Nature, 405:97-101, 2000 Cited by PubMed: 10811226DOI: 10.1038/35011103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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