1CVU

CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2

1CVU の概要

• エントリーDOI: 10.2210/pdb1cvu/pdb
• 関連するPDBエントリー: 1CQE 1LOX 5COX 6COX
• 分子名称: PROSTAGLANDIN H2 SYNTHASE-2, PROTEIN (9-MER), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: cox-2, cyclooxygenase, prostaglandin, arachidonate, endoperoxide, oxidoreductase-peptide complex, oxidoreductase/peptide
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 132599.08

構造登録者

Kiefer, J.R.,Pawlitz, J.L.,Moreland, K.T.,Stegeman, R.A.,Gierse, J.K.,Stevens, A.M.,Goodwin, D.C.,Rowlinson, S.W.,Marnett, L.J.,Stallings, W.C.,Kurumbail, R.G. (登録日: 1999-08-24, 公開日: 2000-05-16, 最終更新日: 2021-11-03)

• 主引用文献: Kiefer, J.R.,Pawlitz, J.L.,Moreland, K.T.,Stegeman, R.A.,Hood, W.F.,Gierse, J.K.,Stevens, A.M.,Goodwin, D.C.,Rowlinson, S.W.,Marnett, L.J.,Stallings, W.C.,Kurumbail, R.G.; Structural insights into the stereochemistry of the cyclooxygenase reaction.; Nature, 405:97-101, 2000; PubMed: 10811226; DOI: 10.1038/35011103

実験手法

X-RAY DIFFRACTION (2.4 Å)