1CPI

REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES. DESIGN OF HYDROLYTICALLY STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE

Summary for 1CPI

Related PRD IDPRD_000407
DescriptorHIV-1 PROTEASE, CYCLIC PEPTIDE INHIBITOR, SULFATE ION, ... (4 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P03369
Total number of polymer chains3
Total molecular weight22585.19
Authors
Martin, J.L. (deposition date: 1995-10-16, release date: 1996-03-08, Last modification date: 2012-12-12)
Primary citation
Abbenante, G.,March, D.R.,Bergman, D.A.,Hunt, P.A.,Garnham, B.,Dancer, R.J.,Martin, J.L.,Fairlie, D.P.
REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES - DESIGN OF HYDROLYTICALLY-STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE.
J.Am.Chem.Soc., 117:10220-10226, 1995
Experimental method
X-RAY DIFFRACTION (2.05 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers403.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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