1CLV

YELLOW MEAL WORM ALPHA-AMYLASE IN COMPLEX WITH THE AMARANTH ALPHA-AMYLASE INHIBITOR

Summary for 1CLV

• Entry DOI: 10.2210/pdb1clv/pdb
• Descriptor: PROTEIN (ALPHA-AMYLASE), PROTEIN (ALPHA-AMYLASE INHIBITOR), CALCIUM ION, ... (5 entities in total)
• Functional Keywords: insect alpha-amylase inhibitor, amaranthus hypochondriacus, yellow meal worm, knottin, hydrolase
• Biological source: Tenebrio molitor (yellow mealworm); More
• Total number of polymer chains: 2
• Total formula weight: 54933.71

Authors

Pereira, P.J.B.,Lozanov, V.,Patthy, A.,Huber, R.,Bode, W.,Pongor, S.,Strobl, S. (deposition date: 1999-05-04, release date: 2000-05-03, Last modification date: 2024-11-20)

Primary citation

Pereira, P.J.,Lozanov, V.,Patthy, A.,Huber, R.,Bode, W.,Pongor, S.,Strobl, S.
Specific inhibition of insect alpha-amylases: yellow meal worm alpha-amylase in complex with the amaranth alpha-amylase inhibitor at 2.0 A resolution.
Structure Fold.Des., 7:1079-1088, 1999

PubMed Abstract: alpha-Amylases constitute a family of enzymes that catalyze the hydrolysis of alpha-D-(1,4)-glucan linkages in starch and related polysaccharides. The Amaranth alpha-amylase inhibitor (AAI) specifically inhibits alpha-amylases from insects, but not from mammalian sources. AAI is the smallest proteinaceous alpha-amylase inhibitor described so far and has no known homologs in the sequence databases. Its mode of inhibition of alpha-amylases was unknown until now.

PubMed: 10508777
DOI: 10.1016/S0969-2126(99)80175-0

Experimental method

X-RAY DIFFRACTION (2 Å)