1CI7

TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII

Summary for 1CI7

• Entry DOI: 10.2210/pdb1ci7/pdb
• Descriptor: PROTEIN (THYMIDYLATE SYNTHASE), 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
• Functional Keywords: methyltransferase, nucleotide biosynthesis, half-sites reactivity, transferase
• Biological source: Pneumocystis carinii
• Total number of polymer chains: 2
• Total formula weight: 69900.40

Authors

Anderson, A.C.,O'Neil, R.H.,Delano, W.L.,Stroud, R.M. (deposition date: 1999-04-08, release date: 2000-04-10, Last modification date: 2024-04-03)

• Primary citation: Anderson, A.C.,O'Neil, R.H.,DeLano, W.L.,Stroud, R.M.; The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits.; Biochemistry, 38:13829-13836, 1999; PubMed: 10529228; DOI: 10.1021/bi991610i

Experimental method

X-RAY DIFFRACTION (2.6 Å)