1CI7
TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE UMP B 765 |
Chain | Residue |
A | ARG153 |
B | ASN210 |
B | HIS240 |
B | TYR242 |
A | ARG154 |
B | ARG26 |
B | LEU170 |
B | CYS173 |
B | ARG199 |
B | SER200 |
B | CYS201 |
B | ASP202 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UMP A 767 |
Chain | Residue |
A | ARG26 |
A | LEU170 |
A | CYS173 |
A | ARG199 |
A | SER200 |
A | CYS201 |
A | ASP202 |
A | ASN210 |
A | HIS240 |
A | TYR242 |
A | CB3768 |
B | ARG153 |
B | ARG154 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CB3 A 768 |
Chain | Residue |
A | ARG56 |
A | PHE58 |
A | ILE86 |
A | ASN90 |
A | ASP202 |
A | GLY206 |
A | PHE209 |
A | ASN210 |
A | TYR242 |
A | MET295 |
A | SER296 |
A | UMP767 |
A | HOH1087 |
Functional Information from PROSITE/UniProt
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrlIlsaWNpadlekma.....LpPCHmfcQFyV |
Chain | Residue | Details |
A | ARG153-VAL181 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P0A884 |
Chain | Residue | Details |
A | CYS173 | |
B | CYS173 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: in other chain => ECO:0000250|UniProtKB:P0A884 |
Chain | Residue | Details |
A | ARG26 | |
A | ARG199 | |
A | ASN210 | |
A | HIS240 | |
B | ARG26 | |
B | ARG199 | |
B | ASN210 | |
B | HIS240 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A884 |
Chain | Residue | Details |
A | ARG153 | |
A | ASP202 | |
B | ARG153 | |
B | ASP202 |