1CI7
TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE UMP B 765 |
| Chain | Residue |
| A | ARG153 |
| B | ASN210 |
| B | HIS240 |
| B | TYR242 |
| A | ARG154 |
| B | ARG26 |
| B | LEU170 |
| B | CYS173 |
| B | ARG199 |
| B | SER200 |
| B | CYS201 |
| B | ASP202 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE UMP A 767 |
| Chain | Residue |
| A | ARG26 |
| A | LEU170 |
| A | CYS173 |
| A | ARG199 |
| A | SER200 |
| A | CYS201 |
| A | ASP202 |
| A | ASN210 |
| A | HIS240 |
| A | TYR242 |
| A | CB3768 |
| B | ARG153 |
| B | ARG154 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CB3 A 768 |
| Chain | Residue |
| A | ARG56 |
| A | PHE58 |
| A | ILE86 |
| A | ASN90 |
| A | ASP202 |
| A | GLY206 |
| A | PHE209 |
| A | ASN210 |
| A | TYR242 |
| A | MET295 |
| A | SER296 |
| A | UMP767 |
| A | HOH1087 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrlIlsaWNpadlekma.....LpPCHmfcQFyV |
| Chain | Residue | Details |
| A | ARG153-VAL181 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P0A884","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"P0A884","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A884","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| A | SER200 | |
| A | ASP238 | |
| A | GLU65 | |
| A | CYS173 | |
| A | HIS240 | |
| A | ASP202 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| B | SER200 | |
| B | ASP238 | |
| B | GLU65 | |
| B | CYS173 | |
| B | HIS240 | |
| B | ASP202 |
