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1CI7

TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII

Functional Information from GO Data
ChainGOidnamespacecontents
A0004146molecular_functiondihydrofolate reductase activity
A0004799molecular_functionthymidylate synthase activity
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006231biological_processdTMP biosynthetic process
A0006235biological_processdTTP biosynthetic process
A0008168molecular_functionmethyltransferase activity
A0009165biological_processnucleotide biosynthetic process
A0016740molecular_functiontransferase activity
A0016741molecular_functiontransferase activity, transferring one-carbon groups
A0032259biological_processmethylation
B0004146molecular_functiondihydrofolate reductase activity
B0004799molecular_functionthymidylate synthase activity
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006231biological_processdTMP biosynthetic process
B0006235biological_processdTTP biosynthetic process
B0008168molecular_functionmethyltransferase activity
B0009165biological_processnucleotide biosynthetic process
B0016740molecular_functiontransferase activity
B0016741molecular_functiontransferase activity, transferring one-carbon groups
B0032259biological_processmethylation
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE UMP B 765
ChainResidue
AARG153
BASN210
BHIS240
BTYR242
AARG154
BARG26
BLEU170
BCYS173
BARG199
BSER200
BCYS201
BASP202

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE UMP A 767
ChainResidue
AARG26
ALEU170
ACYS173
AARG199
ASER200
ACYS201
AASP202
AASN210
AHIS240
ATYR242
ACB3768
BARG153
BARG154

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE CB3 A 768
ChainResidue
AARG56
APHE58
AILE86
AASN90
AASP202
AGLY206
APHE209
AASN210
ATYR242
AMET295
ASER296
AUMP767
AHOH1087

Functional Information from PROSITE/UniProt
site_idPS00091
Number of Residues29
DetailsTHYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrlIlsaWNpadlekma.....LpPCHmfcQFyV
ChainResidueDetails
AARG153-VAL181

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P0A884
ChainResidueDetails
ACYS173
BCYS173

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: in other chain => ECO:0000250|UniProtKB:P0A884
ChainResidueDetails
AARG26
AARG199
AASN210
AHIS240
BARG26
BARG199
BASN210
BHIS240

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P0A884
ChainResidueDetails
AARG153
AASP202
BARG153
BASP202

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PDB entries from 2024-03-27

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