1CDK
CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C
Summary for 1CDK
Entry DOI | 10.2210/pdb1cdk/pdb |
Descriptor | CAMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR, MANGANESE (II) ION, ... (6 entities in total) |
Functional Keywords | complex (transferase-inhibitor), transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Sus scrofa (pig) More |
Cellular location | Cytoplasm: P00517 |
Total number of polymer chains | 4 |
Total formula weight | 87392.52 |
Authors | Bossemeyer, D.,Engh, R.A.,Kinzel, V.,Ponstingl, H.,Huber, R. (deposition date: 1994-07-04, release date: 1995-10-15, Last modification date: 2024-06-05) |
Primary citation | Bossemeyer, D.,Engh, R.A.,Kinzel, V.,Ponstingl, H.,Huber, R. Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24). EMBO J., 12:849-859, 1993 Cited by PubMed: 8384554PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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