1CDK
CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | CAMP-DEPENDENT PROTEIN KINASE | polymer | 350 | 40625.4 | 2 | UniProt (P00517) Pfam (PF00069) UniProt (by SIFTS) (P36887) In PDB | Sus scrofa (pig) | PROTEIN KINASE A |
| 2 | I, J | PROTEIN KINASE INHIBITOR | polymer | 20 | 2226.4 | 2 | UniProt (P61925) UniProt (by SIFTS) (P61926) In PDB | Homo sapiens | PKI(5-24) |
| 3 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 4 | A, B | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 5 | A, B | MYRISTIC ACID | non-polymer | 228.4 | 2 | Chemie (MYR) | |||
| 6 | water | water | 18.0 | 312 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Lys 63 | Met 63 | conflict |
| Phe 69 | Tyr 69 | conflict |
| Tyr 108 | Phe 108 | conflict |
| Asp 286 | Asn 286 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 85703.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1688.9 | |
| All* | Total formula weight | 87392.5 |
