1C8K

FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE

1C8K の概要

• エントリーDOI: 10.2210/pdb1c8k/pdb
• 分子名称: PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, ... (4 entities in total)
• 機能のキーワード: glycogen metabolism, glycogen phosphorylase b, inhibition, inhibitor binding site, antitumour agent, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97940.18

構造登録者

Oikonomakos, N.G.,Zographos, S.E.,Skamnaki, V.T.,Tsitsanou, K.E.,Johnson, L.N. (登録日: 2000-05-11, 公開日: 2000-05-24, 最終更新日: 2023-12-27)

• 主引用文献: Oikonomakos, N.G.,Schnier, J.B.,Zographos, S.E.,Skamnaki, V.T.,Tsitsanou, K.E.,Johnson, L.N.; Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.; J.Biol.Chem., 275:34566-34573, 2000; PubMed: 10924512; DOI: 10.1074/jbc.M004485200

実験手法

X-RAY DIFFRACTION (1.76 Å)