1C1W
RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Summary for 1C1W
Entry DOI | 10.2210/pdb1c1w/pdb |
Related | 1C1N 1C1O 1C1P 1C1Q 1C1R 1C1S 1C1T 1C1U 1C1V 1C2D 1C2E 1C2F 1C2G 1C2H 1C2I 1C2J 1C2L 1C2M |
Descriptor | Thrombin light chain, Thrombin heavy chain, Hirudin-2, ... (7 entities in total) |
Functional Keywords | zn(ii)-mediated serine protease inhibitors, ph dependence, zn(ii) affinity stucture-based drug design, serine protease/inhibitor, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28504 |
Total number of polymer chains | 3 |
Total formula weight | 35953.87 |
Authors | Katz, B.A.,Luong, C. (deposition date: 1999-07-21, release date: 2000-07-26, Last modification date: 2023-11-15) |
Primary citation | Katz, B.A.,Clark, J.M.,Finer-Moore, J.S.,Jenkins, T.E.,Johnson, C.R.,Ross, M.J.,Luong, C.,Moore, W.R.,Stroud, R.M. Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391:608-612, 1998 Cited by PubMed: 9468142DOI: 10.1038/35422 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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