1BXS

SHEEP LIVER CLASS 1 ALDEHYDE DEHYDROGENASE WITH NAD BOUND

1BXS の概要

• エントリーDOI: 10.2210/pdb1bxs/pdb
• 分子名称: ALDEHYDE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: aldehyde dehydrogenase, retinal, class 1, tetramer, nad, cytosolic, oxidoreductase
• 由来する生物種: Ovis aries (sheep)
• 細胞内の位置: Cytoplasm: P51977
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 222196.06

構造登録者

Moore, S.A.,Baker, H.M.,Blythe, T.J.,Kitson, K.E.,Kitson, T.M.,Baker, E.N. (登録日: 1998-10-08, 公開日: 1999-04-27, 最終更新日: 2024-05-22)

主引用文献

Moore, S.A.,Baker, H.M.,Blythe, T.J.,Kitson, K.E.,Kitson, T.M.,Baker, E.N.
Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases.
Structure, 6:1541-1551, 1998

PubMed Abstract: . Enzymes of the aldehyde dehydrogenase family are required for the clearance of potentially toxic aldehydes, and are essential for the production of key metabolic regulators. The cytosolic, or class 1, aldehyde dehydrogenase (ALDH1) of higher vertebrates has an enhanced specificity for all-trans retinal, oxidising it to the powerful differentiation factor all-trans retinoic acid. Thus, ALDH1 is very likely to have a key role in vertebrate development.

PubMed: 9862807
DOI: 10.1016/S0969-2126(98)00152-X

実験手法

X-RAY DIFFRACTION (2.35 Å)