1BWB

HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS

Summary for 1BWB

Entry DOI	10.2210/pdb1bwb/pdb
Descriptor	PROTEIN (HIV-1 PROTEASE), [4R-(4ALPHA,5ALPHA,6ALPHA,7ALPHA)]-3,3'-{{TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-DIYL]BIS(METHYLENE)]BIS[N-1H-BENZIMIDAZOL-2-YLBENZAMIDE] (3 entities in total)
Functional Keywords	hiv-1 protease, hydrolase
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains	2
Total formula weight	22472.42
Authors	Ala, P.,Chang, C.H. (deposition date: 1998-09-22, release date: 1998-09-30, Last modification date: 2024-02-07)
Primary citation	Ala, P.J.,Huston, E.E.,Klabe, R.M.,Jadhav, P.K.,Lam, P.Y.,Chang, C.H. Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities. Biochemistry, 37:15042-15049, 1998 Cited by PubMed: 9790666 DOI: 10.1021/bi980386e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation