1BWB
HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEIN (HIV-1 PROTEASE) | polymer | 99 | 10823.7 | 2 | UniProt (P04585) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C (B) | [4R-(4ALPHA,5ALPHA,6ALPHA,7ALPHA)]-3,3'-{{TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-DIYL]BIS(METHYLENE)]BIS[N-1H-BENZIMIDAZOL-2-YLBENZAMIDE] | non-polymer | 824.9 | 1 | Chemie (146) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Phe 82 | Val 138 | engineered mutation |
| Val 84 | Ile 140 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21647.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 824.9 | |
| All* | Total formula weight | 22472.4 |
