1BQY

Plasminogen activator (TSV-PA) from snake venom

Summary for 1BQY

• Entry DOI: 10.2210/pdb1bqy/pdb
• Related PRD ID: PRD_000288
• Descriptor: PLASMINOGEN ACTIVATOR, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide (3 entities in total)
• Functional Keywords: fibrinolysis, plasminogen activator, serine proteinase, snake venom, hydrolase-hydrolase inhibitor complex, blood clotting, hydrolase/hydrolase inhibitor
• Biological source: Viridovipera stejnegeri (Stejneger's pit viper)
• Total number of polymer chains: 2
• Total formula weight: 52059.77

Authors

Parry, M.A.A.,Bode, W. (deposition date: 1998-08-20, release date: 1999-08-20, Last modification date: 2024-10-30)

Primary citation

Parry, M.A.,Jacob, U.,Huber, R.,Wisner, A.,Bon, C.,Bode, W.
The crystal structure of the novel snake venom plasminogen activator TSV-PA: a prototype structure for snake venom serine proteinases.
Structure, 6:1195-1206, 1998

PubMed Abstract: Trimeresurus stejnejeri venom plasminogen activator (TSV-PA) is a snake venom serine proteinase that specifically activates plasminogen. Snake venom serine proteinases form a subfamily of trypsin-like proteinases that are characterised by a high substrate specificity and resistance to inhibition. Many of these venom enzymes specifically interfere with haemostatic mechanisms and display a long circulating half-life. For these reasons several of them have commercial applications and are potentially attractive pharmacological tools.

PubMed: 9753698
DOI: 10.1016/S0969-2126(98)00119-1

Experimental method

X-RAY DIFFRACTION (2.5 Å)