1BQQ

CRYSTAL STRUCTURE OF THE MT1-MMP--TIMP-2 COMPLEX

Summary for 1BQQ

Entry DOI	10.2210/pdb1bqq/pdb
Descriptor	MEMBRANE-TYPE MATRIX METALLOPROTEINASE, METALLOPROTEINASE INHIBITOR 2, CALCIUM ION, ... (5 entities in total)
Functional Keywords	matrix metalloproteinase, tissue inhibitor of metalloproteinases, proteinase complex, pro-gelatinase a activator, complex (metalloproteinase-receptor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein (Potential): P50281 Secreted: P16368
Total number of polymer chains	2
Total formula weight	40535.47
Authors	Fernandez-Catalan, C.,Bode, W.,Huber, R.,Turk, D.,Calvete, J.J.,Lichte, A.,Tschesche, H.,Maskos, K. (deposition date: 1998-08-18, release date: 1999-08-18, Last modification date: 2011-07-13)
Primary citation	Fernandez-Catalan, C.,Bode, W.,Huber, R.,Turk, D.,Calvete, J.J.,Lichte, A.,Tschesche, H.,Maskos, K. Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor. EMBO J., 17:5238-5248, 1998 Cited by PubMed: 9724659 DOI: 10.1093/emboj/17.17.5238 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation