1BMQ

CRYSTAL STRUCTURE OF THE COMPLEX OF INTERLEUKIN-1BETA CONVERTING ENZYME (ICE) WITH A PEPTIDE BASED INHIBITOR, (3S )-N-METHANESULFONYL-3-({1-[N-(2-NAPHTOYL)-L-VALYL]-L-PROLYL }AMINO)-4-OXOBUTANAMIDE

Summary for 1BMQ

Entry DOI	10.2210/pdb1bmq/pdb
Descriptor	PROTEIN (INTERLEUKIN-1 BETA CONVERTASE), (3S)-N-METHANESULFONYL-3-({1-[N-(2-NAPHTOYL)-L-VALYL]-L-PROLYL}AMINO)-4-OXOBUTANAMIDE (3 entities in total)
Functional Keywords	caspase, hydrolase
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P29466 P29466
Total number of polymer chains	2
Total formula weight	29614.10
Authors	Okamoto, Y.,Anan, H.,Nakai, E.,Morihira, K.,Yonetoku, Y.,Kurihara, H.,Katayama, N.,Sakashita, H.,Terai, Y.,Takeuchi, M.,Shibanuma, T.,Isomura, Y. (deposition date: 1998-07-24, release date: 1998-07-29, Last modification date: 2023-08-09)
Primary citation	Okamoto, Y.,Anan, H.,Nakai, E.,Morihira, K.,Yonetoku, Y.,Kurihara, H.,Sakashita, H.,Terai, Y.,Takeuchi, M.,Shibanuma, T.,Isomura, Y. Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex. Chem.Pharm.Bull., 47:11-21, 1999 Cited by PubMed: 9987822 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation