Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008234 | molecular_function | cysteine-type peptidase activity |
B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE MNO A 601 |
Chain | Residue |
A | PRO177 |
A | ARG179 |
A | HIS237 |
A | GLY238 |
A | CYS285 |
B | SER339 |
B | TRP340 |
B | ARG341 |
B | ARG383 |
Functional Information from PROSITE/UniProt
site_id | PS01121 |
Number of Residues | 15 |
Details | CASPASE_HIS Caspase family histidine active site. HktsdStfLvFMSHG |
Chain | Residue | Details |
A | HIS224-GLY238 | |
site_id | PS01122 |
Number of Residues | 12 |
Details | CASPASE_CYS Caspase family cysteine active site. KPKVIIIQACRG |
Chain | Residue | Details |
A | LYS276-GLY287 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | HIS237 | |
Chain | Residue | Details |
A | CYS285 | |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:30065070 |
Chain | Residue | Details |
A | LYS134 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1qx3 |
Chain | Residue | Details |
A | CYS285 | |
A | HIS237 | |
A | GLY238 | |
site_id | MCSA1 |
Number of Residues | 1 |
Details | M-CSA 718 |
Chain | Residue | Details |
B | GLU390 | electrostatic stabiliser |
A | GLY238 | electrostatic stabiliser |
A | CYS285 | nucleofuge, nucleophile, proton acceptor, proton donor |
A | ARG286 | electrostatic stabiliser |