1BJG

D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING

1BJG の概要

• エントリーDOI: 10.2210/pdb1bjg/pdb
• 分子名称: THYMIDYLATE SYNTHASE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID, ... (4 entities in total)
• 機能のキーワード: transferase, active site mutant, reaction intermediate methyltransferase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A884
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31340.27

構造登録者

Sage, C.R.,Michelitsch, M.D.,Finer-Moore, J.,Stroud, R.M. (登録日: 1998-06-25, 公開日: 1998-11-04, 最終更新日: 2024-04-03)

• 主引用文献: Sage, C.R.,Michelitsch, M.D.,Stout, T.J.,Biermann, D.,Nissen, R.,Finer-Moore, J.,Stroud, R.M.; D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.; Biochemistry, 37:13893-13901, 1998; PubMed: 9753479; DOI: 10.1021/bi9810510

実験手法

X-RAY DIFFRACTION (2.3 Å)