1BIF

6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE BIFUNCTIONAL ENZYME COMPLEXED WITH ATP-G-S AND PHOSPHATE

Summary for 1BIF

Entry DOI	10.2210/pdb1bif/pdb
NMR Information	BMRB: 5935
Descriptor	6-PHOSPHOFRUCTO-2-KINASE/ FRUCTOSE-2,6-BISPHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	kinase, transferase (phospho), phosphatase, hydrolase (phospho), glycolysis, bifunctional enzyme
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	1
Total formula weight	54898.17
Authors	Hasemann, C.A.,Deisenhofer, J. (deposition date: 1996-11-08, release date: 1997-11-12, Last modification date: 2024-02-07)
Primary citation	Hasemann, C.A.,Istvan, E.S.,Uyeda, K.,Deisenhofer, J. The crystal structure of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase reveals distinct domain homologies. Structure, 4:1017-1029, 1996 Cited by PubMed Abstract: Glucose homeostasis is maintained by the processes of glycolysis and gluconeogenesis. The importance of these pathways is demonstrated by the severe and life threatening effects observed in various forms of diabetes. The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase catalyzes both the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis. Thus this bifunctional enzyme plays an indirect yet key role in the regulation of glucose metabolism. PubMed: 8805587 DOI: 10.1016/S0969-2126(96)00109-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation