1BI7

MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX

1BI7 の概要

• エントリーDOI: 10.2210/pdb1bi7/pdb
• 分子名称: CYCLIN-DEPENDENT KINASE 6, MULTIPLE TUMOR SUPPRESSOR (2 entities in total)
• 機能のキーワード: cyclin dependent kinase, cyclin dependent kinase inhibitory protein, cdk, ink4, cell cycle, multiple tumor suppressor, mts1, complex (kinase-anti-oncogene), complex (kinase-anti-oncogene) complex, complex (kinase/anti-oncogene)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P42771
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53542.91

構造登録者

Russo, A.A.,Tong, L.,Lee, J.O.,Jeffrey, P.D.,Pavletich, N.P. (登録日: 1998-06-22, 公開日: 1999-01-13, 最終更新日: 2024-02-07)

• 主引用文献: Russo, A.A.,Tong, L.,Lee, J.O.,Jeffrey, P.D.,Pavletich, N.P.; Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.; Nature, 395:237-243, 1998; PubMed: 9751050; DOI: 10.1038/26155

実験手法

X-RAY DIFFRACTION (3.4 Å)