1B5G
HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN
Summary for 1B5G
Entry DOI | 10.2210/pdb1b5g/pdb |
Descriptor | ALPHA-THROMBIN, HIRUGEN, [[[(4S,5S)-4-[[(3S,6S,8aR)-6-azanyl-5-oxo-6-(phenylmethyl)-1,2,3,7,8,8a-hexahydroindolizin-3-yl]carbonylamino]-5-(1,3-b enzothiazol-2-yl)-5-hydroxy-pentyl]amino]-azanyl-methylidene]azanium, ... (6 entities in total) |
Functional Keywords | serine protease-inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P09945 Secreted: P00734 |
Total number of polymer chains | 3 |
Total formula weight | 36022.01 |
Authors | St Charles, R.,Tulinsky, A.,Kahn, M. (deposition date: 1998-03-05, release date: 1998-05-27, Last modification date: 2024-06-05) |
Primary citation | St Charles, R.,Matthews, J.H.,Zhang, E.,Tulinsky, A. Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin. J.Med.Chem., 42:1376-1383, 1999 Cited by PubMed: 10212123DOI: 10.1021/jm980052n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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