1AY9

WILD-TYPE UMUD' FROM E. COLI

Summary for 1AY9

• Entry DOI: 10.2210/pdb1ay9/pdb
• Descriptor: UMUD PROTEIN (2 entities in total)
• Functional Keywords: mutagenesis protein, dna repair, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 23334.54

Authors

Peat, T.S.,Frank, E.G.,Mcdonald, J.P.,Levine, A.S.,Woodgate, R.,Hendrickson, W.A. (deposition date: 1997-11-15, release date: 1998-01-28, Last modification date: 2024-05-22)

Primary citation

Peat, T.S.,Frank, E.G.,McDonald, J.P.,Levine, A.S.,Woodgate, R.,Hendrickson, W.A.
The UmuD' protein filament and its potential role in damage induced mutagenesis.
Structure, 4:1401-1412, 1996

PubMed Abstract: Damage induced 'SOS mutagenesis' may occur transiently as part of the global SOS response to DNA damage in bacteria. A key participant in this process is the UmuD protein, which is produced in an inactive from but converted to the active form, UmuD', by a RecA-mediated self-cleavage reaction. UmuD', together with UmuC and activated RecA (RecA*), enables the DNA polymerase III holoenzyme to replicate across chemical and UV induced lesions. The efficiency of this reaction depends on several intricate protein-protein interactions.

PubMed: 8994967
DOI: 10.1016/S0969-2126(96)00148-7

Experimental method

X-RAY DIFFRACTION (3 Å)