1AVS
X-RAY CRYSTALLOGRAPHIC STUDY OF CALCIUM-SATURATED N-TERMINAL DOMAIN OF TROPONIN C
Summary for 1AVS
| Entry DOI | 10.2210/pdb1avs/pdb |
| Descriptor | TROPONIN C, CALCIUM ION (3 entities in total) |
| Functional Keywords | muscle contraction, calcium-activated, troponin, e-f hand calcium-binding protein |
| Biological source | Gallus gallus (chicken) |
| Total number of polymer chains | 2 |
| Total formula weight | 20128.48 |
| Authors | Strynadka, N.C.J.,James, M.N.G. (deposition date: 1997-09-19, release date: 1997-12-24, Last modification date: 2024-05-22) |
| Primary citation | Strynadka, N.C.,Cherney, M.,Sielecki, A.R.,Li, M.X.,Smillie, L.B.,James, M.N. Structural details of a calcium-induced molecular switch: X-ray crystallographic analysis of the calcium-saturated N-terminal domain of troponin C at 1.75 A resolution. J.Mol.Biol., 273:238-255, 1997 Cited by PubMed Abstract: We have solved and refined the crystal and molecular structures of the calcium-saturated N-terminal domain of troponin C (TnC) to 1.75 A resolution. This has allowed for the first detailed analysis of the calcium binding sites of this molecular switch in the calcium-loaded state. The results provide support for the proposed binding order and qualitatively, for the affinity of calcium in the two regulatory calcium binding sites. Based on a comparison with the high-resolution apo-form of TnC we propose a possible mechanism for the calcium-mediated exposure of a large hydrophobic surface that is central to the initiation of muscle contraction within the cell. PubMed: 9367759DOI: 10.1006/jmbi.1997.1257 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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