1AOW

ANNEXIN IV

Summary for 1AOW

• Entry DOI: 10.2210/pdb1aow/pdb
• Descriptor: ANNEXIN IV (1 entity in total)
• Functional Keywords: calcium/phospholipid-binding protein, 32.5kd calelectrin, endonexin i, lipocortin iv, chromobindin iv, protein ii, calcium-phospholipid-binding protein complex
• Biological source: Bos taurus (cattle)
• Total number of polymer chains: 1
• Total formula weight: 35005.65

Authors

Zanotti, G.,Malpeli, G.,Gliubich, F.,Folli, C.,Stoppini, M.,Olivi, L.,Savoia, A.,Berni, R. (deposition date: 1997-07-11, release date: 1998-01-14, Last modification date: 2024-05-22)

Primary citation

Zanotti, G.,Malpeli, G.,Gliubich, F.,Folli, C.,Stoppini, M.,Olivi, L.,Savoia, A.,Berni, R.
Structure of the trigonal crystal form of bovine annexin IV.
Biochem.J., 329:101-106, 1998

PubMed Abstract: The structure of a trigonal crystal form of N-terminally truncated [des-(1-9)] bovine annexin IV, an annexin variant that exhibits the distinctive property of binding both phospholipids and carbohydrates in a Ca2+-dependent manner, has been determined at 3 A (0.3 nm) resolution -space group: R3; cell parameters: a=b=118.560 (8) A and c=82.233 (6) A-. The overall structure of annexin IV, crystallized in the absence of Ca2+ ions, is highly homologous to that of the other known members of the annexin family. The trimeric assembly in the trigonal crystals of annexin IV is quite similar to that found previously in non-isomorphous crystals of human, chicken and rat annexin V and to the subunit arrangement in half of the hexamer of hydra annexin XII. Moreover, it resembles that found in two-dimensional crystals of human annexin V bound to phospholipid monolayers. The propensity of several annexins to generate similar trimeric arrays supports the hypothesis that trimeric complexes of such annexins, including annexin IV, may represent the functional units that interact with membranes.

PubMed: 9405281

Experimental method

X-RAY DIFFRACTION (3 Å)