1ALA

STRUCTURE OF CHICKEN ANNEXIN V AT 2.25-ANGSTROMS RESOLUTION

Summary for 1ALA

• Entry DOI: 10.2210/pdb1ala/pdb
• Descriptor: ANNEXIN V, CALCIUM ION (3 entities in total)
• Functional Keywords: calcium/phospholipid-binding protein, calcium-phospholipid-binding protein complex
• Biological source: Gallus gallus (chicken)
• Total number of polymer chains: 1
• Total formula weight: 36382.59

Authors

Waller, D.A.,Bewley, M.C.,Huber, R. (deposition date: 1993-01-14, release date: 1993-10-31, Last modification date: 2024-02-07)

Primary citation

Bewley, M.C.,Boustead, C.M.,Walker, J.H.,Waller, D.A.,Huber, R.
Structure of chicken annexin V at 2.25-A resolution.
Biochemistry, 32:3923-3929, 1993

PubMed Abstract: The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 A. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.

PubMed: 8471604
DOI: 10.1021/bi00066a011

Experimental method

X-RAY DIFFRACTION (2.25 Å)