1AKN

STRUCTURE OF BILE-SALT ACTIVATED LIPASE

Summary for 1AKN

• Entry DOI: 10.2210/pdb1akn/pdb
• Descriptor: BILE-SALT ACTIVATED LIPASE, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• Functional Keywords: hydrolase, serine esterase, lipid degradation, glycoprotein, carboxylic esterase, hydrolase()
• Biological source: Bos taurus (cattle)
• Total number of polymer chains: 1
• Total formula weight: 63832.57

Authors

Wang, X.,Zhang, X. (deposition date: 1997-05-23, release date: 1998-05-27, Last modification date: 2024-10-09)

Primary citation

Wang, X.,Wang, C.S.,Tang, J.,Dyda, F.,Zhang, X.C.
The crystal structure of bovine bile salt activated lipase: insights into the bile salt activation mechanism.
Structure, 5:1209-1218, 1997

PubMed Abstract: The intestinally located pancreatic enzyme, bile salt activated lipase (BAL), possesses unique activities for digesting different kinds of lipids. It also differs from other lipases in a requirement of bile salts for activity. A structure-based explanation for these unique properties has not been reached so far due to the absence of a three-dimensional structure.

PubMed: 9331420
DOI: 10.1016/S0969-2126(97)00271-2

Experimental method

X-RAY DIFFRACTION (2.8 Å)