Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1AKN

STRUCTURE OF BILE-SALT ACTIVATED LIPASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0004771molecular_functionsterol ester esterase activity
A0004806molecular_functiontriacylglycerol lipase activity
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0008126molecular_functionacetylesterase activity
A0016042biological_processlipid catabolic process
A0030157biological_processpancreatic juice secretion
A0042572biological_processretinol metabolic process
A0046514biological_processceramide catabolic process
A0050253molecular_functionretinyl-palmitate esterase activity
A0052689molecular_functioncarboxylic ester hydrolase activity
Functional Information from PROSITE/UniProt
site_idPS00122
Number of Residues16
DetailsCARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpdnItLfGeSAG
ChainResidueDetails
APHE181-GLY196

site_idPS00941
Number of Residues11
DetailsCARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIWvP
ChainResidueDetails
AGLU78-PRO88

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Acyl-ester intermediate
ChainResidueDetails
ASER194

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AASP320
AHIS435

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AASN187
AASN361

Catalytic Information from CSA
site_idCSA1
Number of Residues6
DetailsAnnotated By Reference To The Literature 1aql
ChainResidueDetails
AGLY107
AHIS435
AALA195
AASP320
ASER194
AALA108

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1aql
ChainResidueDetails
AASP294
AHIS322
ASER194

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1aql
ChainResidueDetails
AASP292
AHIS322
ASER194

site_idMCSA1
Number of Residues6
DetailsM-CSA 401
ChainResidueDetails
AGLY107electrostatic stabiliser
AALA108electrostatic stabiliser
ASER194covalent catalysis
AALA195electrostatic stabiliser
AASP320activator, electrostatic stabiliser
AHIS435proton shuttle (general acid/base)

226707

PDB entries from 2024-10-30

PDB statisticsPDBj update infoContact PDBjnumon