1AFC

STRUCTURAL STUDIES OF THE BINDING OF THE ANTI-ULCER DRUG SUCROSE OCTASULFATE TO ACIDIC FIBROBLAST GROWTH FACTOR

1AFC の概要

• エントリーDOI: 10.2210/pdb1afc/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900013
• 分子名称: ACIDIC FIBROBLAST GROWTH FACTOR, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose (2 entities in total)
• 機能のキーワード: growth factor
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 134830.48

構造登録者

Zhu, X.,Hsu, B.T.,Rees, D.C. (登録日: 1993-07-13, 公開日: 1993-10-31, 最終更新日: 2024-02-07)

主引用文献

Zhu, X.,Hsu, B.T.,Rees, D.C.
Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor.
Structure, 1:27-34, 1993

PubMed Abstract: The anti-ulcer drug sucrose octasulfate (SOS) binds to fibroblast growth factors (FGFs), proteins which stimulate the growth and differentiation of several cell types, including stomach epithelial cells. It is believed that SOS stabilizes FGFs against acid denaturation in the stomach, thus enhancing their ability to stimulate healing of ulcerated tissue. SOS binds to the same site on FGF as heparin and other proteoglycans; in vivo, FGF must bind to cell-surface proteoglycans or to heparin before it can interact with FGF receptors and stimulate growth. The details of this process are not understood.

PubMed: 7520817
DOI: 10.1016/0969-2126(93)90006-3

実験手法

X-RAY DIFFRACTION (2.7 Å)