1AD8

COMPLEX OF THROMBIN WITH AND INHIBITOR CONTAINING A NOVEL P1 MOIETY

Summary for 1AD8

DescriptorTHROMBIN (SMALL SUBUNIT), THROMBIN (LARGE SUBUNIT), HIRUDIN (53-65) PEPTIDE, ... (6 entities in total)
Functional Keywordscomplex (serine protease-inhibitor), hydrolase, serine protease, coagulant, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHirudo medicinalis (medicinal leech)
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Cellular locationSecreted, extracellular space P00734 P00734
Secreted P01050
Total number of polymer chains3
Total molecular weight35827.69
Authors
Schreuder, H.,Tardif, C.,Malikayil, J.A. (deposition date: 1997-02-24, release date: 1997-11-12, Last modification date: 2011-07-13)
Primary citation
Malikayil, J.A.,Burkhart, J.P.,Schreuder, H.A.,Broersma Jr., R.J.,Tardif, C.,Kutcher 3rd., L.W.,Mehdi, S.,Schatzman, G.L.,Neises, B.,Peet, N.P.
Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
Biochemistry, 36:1034-1040, 1997
PubMed: 9033393 (PDB entries with the same primary citation)
DOI: 10.1021/bi9622231
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers7 0.7% 4.0% 5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171313
PDB entries from 2020-11-18