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1A86

MMP8 WITH MALONIC AND ASPARTIC ACID BASED INHIBITOR

Summary for 1A86
Entry DOI10.2210/pdb1a86/pdb
Related PRD IDPRD_000371
DescriptorMMP-8, N-benzyl-N~2~-[(2R)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-alpha-asparagine, CALCIUM ION, ... (4 entities in total)
Functional Keywordscollagenase, matrix metalloproteinase, malonic acid, mmp8, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasmic granule: P22894
Total number of polymer chains1
Total formula weight18202.50
Authors
Brandstetter, H.,Roedern, E.G.V.,Grams, F.,Engh, R.A. (deposition date: 1998-04-03, release date: 1999-05-04, Last modification date: 2024-02-07)
Primary citationBrandstetter, H.,Engh, R.A.,Von Roedern, E.G.,Moroder, L.,Huber, R.,Bode, W.,Grams, F.
Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data.
Protein Sci., 7:1303-1309, 1998
Cited by
PubMed: 9655333
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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