1A85

MMP8 WITH MALONIC AND ASPARAGINE BASED INHIBITOR

Summary for 1A85

Related PRD IDPRD_000249
DescriptorMMP-8, CALCIUM ION, ZINC ION, ... (4 entities in total)
Functional Keywordscollagenase, matrix metalloproteinase, malonic acid, mmp8, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasmic granule P22894
Total number of polymer chains1
Total molecular weight18216.53
Authors
Brandstetter, H.,Roedern, E.G.V.,Grams, F.,Engh, R.A. (deposition date: 1998-04-03, release date: 1999-04-27, Last modification date: 2012-12-12)
Primary citation
Brandstetter, H.,Engh, R.A.,Von Roedern, E.G.,Moroder, L.,Huber, R.,Bode, W.,Grams, F.
Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data.
Protein Sci., 7:1303-1309, 1998
PubMed: 9655333 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1106.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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