1A5V
ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION
Summary for 1A5V
Entry DOI | 10.2210/pdb1a5v/pdb |
Descriptor | INTEGRASE, MANGANESE (II) ION, 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID, ... (4 entities in total) |
Functional Keywords | hydrolase, endonuclease, hiv-1 integrase inhibitor |
Biological source | Rous sarcoma virus (strain Schmidt-Ruppin) |
Cellular location | Matrix protein p19: Virion (Potential). Capsid protein p27: Virion (Potential). Nucleocapsid protein p12: Virion (Potential): P03354 |
Total number of polymer chains | 1 |
Total formula weight | 17815.21 |
Authors | Lubkowski, J.,Yang, F.,Alexandratos, J.,Wlodawer, A. (deposition date: 1998-02-18, release date: 1998-05-27, Last modification date: 2024-05-22) |
Primary citation | Lubkowski, J.,Yang, F.,Alexandratos, J.,Wlodawer, A.,Zhao, H.,Burke Jr., T.R.,Neamati, N.,Pommier, Y.,Merkel, G.,Skalka, A.M. Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. Proc.Natl.Acad.Sci.USA, 95:4831-4836, 1998 Cited by PubMed: 9560188DOI: 10.1073/pnas.95.9.4831 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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