1A31

HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

Summary for 1A31

• Entry DOI: 10.2210/pdb1a31/pdb
• Descriptor: DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*5IUP*5IUP*5IUP*5IUP*CP*AP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), PROTEIN (TOPOISOMERASE I), ... (4 entities in total)
• Functional Keywords: topoisomerase i/dna, dna, topoisomerase i, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleolus :
• Total number of polymer chains: 3
• Total formula weight: 84733.38

Authors

Redinbo, M.R.,Stewart, L.,Kuhn, P.,Champoux, J.J.,Hol, W.G.J. (deposition date: 1998-01-27, release date: 1998-08-28, Last modification date: 2011-07-13)

• Primary citation: Redinbo, M.R.,Stewart, L.,Kuhn, P.,Champoux, J.J.,Hol, W.G.; Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.; Science, 279:1504-1513, 1998; PubMed: 9488644; DOI: 10.1126/science.279.5356.1504

Experimental method

X-RAY DIFFRACTION (2.1 Å)