1A0H
THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN
Summary for 1A0H
Entry DOI | 10.2210/pdb1a0h/pdb |
Related PRD ID | PRD_000020 |
Descriptor | MEIZOTHROMBIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (5 entities in total) |
Functional Keywords | serine protease, coagulation, thrombin, prothrombin, meizothrombin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Bos taurus (cattle) More |
Total number of polymer chains | 4 |
Total formula weight | 97038.29 |
Authors | Martin, P.D.,Malkowski, M.G.,Box, J.,Esmon, C.T.,Edwards, B.F.P. (deposition date: 1997-11-30, release date: 1998-06-17, Last modification date: 2024-04-03) |
Primary citation | Martin, P.D.,Malkowski, M.G.,Box, J.,Esmon, C.T.,Edwards, B.F. New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK. Structure, 5:1681-1693, 1997 Cited by PubMed: 9438869DOI: 10.1016/S0969-2126(97)00314-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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